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Before you buy, read the description of the drug.

 

Xenical - a powerful and specific inhibitor of gastrointestinal lipases. Reduces the amount of calories entering the body, which leads to a decrease in body weight. Is used to treat obese or overweight, combined with moderate calorie diet. 

Properties / Effects Xenical: 

Xenical (orlistat) - a potent and specific inhibitor of gastrointestinal lipases, has duration of action. 

Therapeutic effect of Xenical is carried in the lumen of the stomach and small intestine. Mechanism of action of Xenical is associated with the formation of a covalent bond with the active serine site of gastric and pancreatic lipases. Inactivated enzyme loses the ability to break down fat foods that come in the form of triglycerides, the suction free fatty acids and monoglycerides. As a consequence, decreases the amount of calories entering the body (unsplit triglycerides are not absorbed), which leads to a decrease in body weight. 

Thus, the therapeutic effect of Xenical is performed without suction into the systemic circulation. 

The action of Xenical is to increase the concentration of fat in the stool within 24-48 hours after ingestion. After the abolition of Xenical concentration of fat in the stool back to its initial level (which occurred before the start of therapy) in 48-72 hours 

Pharmacokinetics of Xenical: 

Studies in volunteers with normal body weight and obesity show that the absorption of Xenical is minimal. After receiving 360 mg of Xenical orlistat is unchanged inside the plasma could not be determined, which means that its concentration is below the level of 5 ng / ml. In general, after receiving therapeutic doses of Xenical reveal unchanged orlistat in plasma could only sporadically, with its concentration was extremely low (<10 ng / ml or 0.02 mmol). No signs of accumulation, which confirms that the absorption of Xenical is minimal. The volume of distribution can not be determined because Xenical very poorly absorbed. In vitro orlistat is more than 99% bound to plasma proteins (mainly to lipoproteins and albumin). In a minimum amount orlistat can penetrate into red blood cells. Judging from data obtained in animal experiments, the metabolism of orlistat is carried out mainly on predsistemnom level. Approximately 42% of the minimum fraction of orlistat, which is subjected to systemic absorption in patients with obesity, accounts for two main metabolites - M1 and M3. Molecules M1 and M3 weakly inhibit lipase (respectively, in 1000, and 2500 times weaker than orlistat). In view of this low inhibitory activity and low plasma concentrations (mean, 26 ng / ml and 108 ng / ml, respectively) after administration of therapeutic doses of Xenical, these metabolites are considered pharmacologically inactive. Studies in patients with normal and overweight have shown that the main route of elimination is excretion nevsosavshegosya orlistat in the faeces. Excreted in feces for about 97% of the dose Xenical, and 83% - as unchanged orlistat. Cumulative renal excretion of all substances, structurally related to orlistat is less than 2% of the dose. Time to complete elimination of Xenical from the body (with feces and urine) is equal to 3-5 days. Value tract excretion of orlistat in volunteers with normal and overweight were the same. As orlistat, and metabolites M1 and M3 may be subject to biliary excretion. 

Indications Xenical: 

Xenical is used to treat obese or overweight, combined with moderate calorie diet. 

Dosing and dose of Xenical: 

The recommended dose of Xenical - one capsule of 120 mg with each main meal. Xenical should be taken with food or not later than 1 hour after meals. If the meal is passed or if the food contains no fat, then taking Xenical can also be skipped. 

The patient should receive a balanced, moderately hypocaloric diet containing no more than 30% kalorazha in the form of fat. Daily consumption of fats, carbohydrates and protein should be distributed in three main reception. 

Increasing the dose of Xenical over the recommended (120 mg 3 times daily) did not enhance its therapeutic effect. 

The action of Xenical in patients with liver or kidney disease in children has not been studied. 

An overdose of Xenical: 

 Xenical overdose are not described. In clinical studies in patients with normal weight and obese patients receiving single doses of 800 mg or multiple receiving Xenical 400 mg 3 times daily for 15 days was not accompanied by the appearance of significant adverse events. In addition, obese patients have experience of using Xenical to 240 mg 3 times daily for 6 months. 

In the case of severe overdose of Xenical is recommended to observe the patient within 24 hours. According to studies in humans and animals, any systemic effects, which could be attributed to lipazoingibiruyuschimi properties of orlistat should be rapidly reversible. 

Contraindications Xenical: 

chronic malabsorption syndrome; 

cholestasis; 

idiosyncrasy (including history of hypersensitivity), orlistat, or other components of Xenical. 

Application of pregnancy and breastfeeding: 

Xenical belongs to the category of drug B. 

In reproduction studies in animals teratogenic and embryotoxic effect of Xenical is not observed. In the absence of teratogenic effects in animals to expect a similar effect in humans should not be. However, due to lack of clinical data supporting the safety of Xenical, it should not be prescribed for pregnant women. 

Excretion of orlistat in breast milk has not been studied, therefore it should not take Xenical while breastfeeding. 

Side effects of Xenical: 

In clinical trials, adverse reactions to Xenical arose mainly from the gastrointestinal tract and were caused by the pharmacological action of orlistat, prevents the absorption of fat food. 

Frequently observed phenomena such as oily discharge from the rectum, the allocation of gas with some amount of discharge, compelling urge to stool, steatorrhea, increased frequency of defecation and fecal incontinence. Typically, these side effects are only mild and transient. They arose in the early stages of treatment Xenicalom (the first 3 months), and most patients were no more than one episode of such reactions. 

In addition, from the gastrointestinal tract may experience the following adverse events: pain or abdominal discomfort, bloating, loose stools, soft stools, abdominal pain or discomfort in the rectum, the defeat of the teeth, damage to the gums. 

Described rare cases of hypersensitivity, which was to itching, rash, urticaria, angioedema and anaphylaxis. 

Rarely in patients receiving Xenical marked infection of the upper or lower respiratory tract, flu, headaches, dysmenorrhea, anxiety, fatigue, urinary tract infections, but they were regarded as not involving the use of Xenical. 

Special warnings and precautions Xenical: 

Patients should be informed of the possibility of side effects of the gastrointestinal tract and teach how to address them through better diet, particularly in respect of the quantity it contains fat. Patients should be advised to diet, because the chance of side effects of the gastrointestinal tract may increase if Xenical take on the background of a diet rich in fats (eg 2000 kcal / day, more than 30% as fat, which equals about 67 grams of fat ). The use of low-fat diet reduces the risk of adverse effects on the gastro-intestinal tract. 

In clinical trials, most patients the concentration of vitamins (vitamin A, vitamin D2, vitamin D3, vitamin E, vitamin K) and beta-carotene in the course of two full years of therapy Xenicalom remained within normal limits. To ensure an adequate supply of nutrients can be assigned multivitamins. If the assigned multivitamin, it is better to take no less than 2 hours after taking Xenical, or before bedtime. 

Safety and efficacy of Xenical in patients with impaired liver function and / or kidney disease has not been established. 

Safety of Xenical in children has not been established. 

Drug Interactions Xenical: 

Xenical interactions with digoxin, metformin, phenytoin, warfarin, oral contraceptives (Belarus, Jeanine, Yarin, logest, trikvilar, Novinet, etc.), nifedipine, statins (atorvastatin, lovastatin, pravastatin, rosuvastatin, simvastatin, fluvastatin) and alcohol is not mentioned . 

Should bear in mind the possibility of reducing intake of fat-soluble vitamins (vitamins A, D, E, K). 

Weight loss treatment Xenicalom can improve the compensation of metabolism in patients with diabetes and require reducing the dose of oral hypoglycemic agents (glikvidon, glyburide, gliclazide, glimepiride, tolbutamide, glipizide, repaglinide, metformin, acarbose, glibomet, aktos, Avandia). 

Storage conditions Xenical: 

Store in a dry place at temperatures not above 25 ° C. 

Shelf life 3 years.