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Buy Naprosyn
This drug is in the category: "Pain medicine"
Generic Naprosyn (NAPROXEN) is a Non-Steroidal Anti-Inflammatory Drug (NSAID) used to relieve pain and swelling (inflammation). It is also used to treat headaches, muscle aches, backaches, tendonitis, bursitis, dental pain, menstrual cramps, arthritis, or gout. Generic Naprosyn may be used to reduce fever, or relieve minor aches and pain due to the common cold or flu. It may be used to treat other conditions as determined by your doctor. This medicine works by blocking the enzyme in your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain, swelling, and fever.
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Before you buy, read the description of the drug.
NAPROSYN
Composition NAPROSYN
One tablet contains: Naproxen 250 mg
Pharmacological properties NAPROSYN
Naprosyn has a strong analgesic, anti-inflammatory and antipyretic effect. Active ingredient naproxen, non-steroidal derivative of propionic acid, inhibits the synthesis of prostaglandins. Prostaglandins play an important role in the genesis of inflammation, pain and temperature of the reaction.
Pharmacokinetics NAPROSYN
Suction Naproxen is rapidly and completely absorbed from the gastrointestinal tract. Significant drug concentrations in plasma are attained within 1 hour and maximum concentrations - 2-4 hours. The type and amount of the ingested food only marginally affect the suction process. Distribution More than 99% of the active substance binds to serum albumin.
Metabolism and excretion of NAPROSYN
The half-life from plasma is approximately 13 hours. About 95% of the dose Naprosyna excreted in the urine as unchanged naproxen, an inactive 6-demetilnaproksena or naproxen conjugates.
Indications NAPROSYN
Symptomatic treatment of acute and chronic pain associated with inflammatory and degenerative rheumatic diseases group (rheumatoid arthritis, arthritis, ankylosing spondylitis), extraarticular rheumatism (bursitis, tendinitis, lumbago, etc.), dysmenorrhea, surgery and trauma, acute attack of gout.
Dosing and dosing regimen Naprosyn
Tablets should be taken without chewing, possibly with a small amount of fluid (eg water, milk, tea, fruit juice). Adults: Inflammatory and degenerative rheumatic diseases of the joints: the initial dose and during exacerbation - 1000 mg per day. Maintenance dose, depending on the intensity of pain - from 500 to 1000 mg per day. Extraarticular rheumatism, post-operative and post-traumatic pain: a daily dose - usually 1000 mg. It should match the individual needs of the patient, without exceeding the 1250 mg. The daily dose can be taken once at night or in two divided doses at intervals of 12 hours. Dysmenorrhea: initial dose - 500 mg, maintenance - 250 mg every 6-8 hours for 3-4 days. Gout: the initial dose - 750 mg, maintenance - 250 mg every 8 hours until the attack. Children (over 1 year): Daily dose of juvenile rheumatoid arthritis - 10 mg / kg body weight, divided into 2 doses at intervals of 12 hours.
Naprosyn Dosing in special cases
In patients with liver disease, as well as in elderly patients should be cautious, choosing the smallest of the effective dose.
Contra Naprosyn
Hypersensitivity to naproxen or naproxen sodium, stomach ulcer and duodenal ulcer in the acute stage, are allergic to aspirin or other nonsteroidal anti-inflammatory and analgesic drugs.
Side effects of Naprosyn
In general, Naprosyn well tolerated. Relatively frequent: gastrointestinal disorders (nausea, vomiting, unpleasant oshuscheniya in the epigastrium, feeling of fullness, diarrhea). Less common: the central nervous system (headache, difficulty concentrating, disturbance of thinking, insomnia, tinnitus, hearing loss, vertigo). Observed less than 1% of cases: peptic ulcer and nepepticheskie, bleeding and perforation of ulcers in the gastrointestinal tract, colitis, anaphylactoid reactions, jaundice and hepatitis, ulcerative stomatitis, eosinophilic pneumonia, nephropathy, hematuria, thrombocytopenia, granulocytopenia, aplastic and haemolytic anemia, exudative erythema multiforme (including Stevens-Johnson syndrome), vasculitis, porfirodermatoz, photosensitivity of skin, which manifests itself in the form of bullous epidermolysis, and epidermal necrolysis, cutaneous reactions and angioedema, alopecia. Although the study of drug metabolism characteristics sodium retention have been identified, individual patients had lung peripheral edema.
Precautions Naprosyn
In patients with a known predisposition to gastro-intestinal diseases Naprosyn may only be used under strict medical supervision. When you receive a non-steroidal anti-inflammatory drugs adverse effects on the gastro-intestinal tract in such patients may appear at any time, without symptoms, precursors, and regardless of the duration of treatment. Since Naprosyn and its metabolites are primarily in the urine, caution should be exercised in the appointment of the drug to patients with renal insufficiency. In such cases, we recommend monitoring serum creatinine in serum and / or creatinine clearance. Naprosyn should not be used for a long time in patients with creatinine clearance below 20 ml / min. In patients with impaired renal plasma flow, such as a decrease in extracellular volume, liver cirrhosis, hyponatremia, congestive heart failure, pre-existing renal disease or renal failure, age is recommended to monitor kidney function before and during treatment Naprosynom. In these cases you need to consider reducing the daily dose to avoid the likelihood of excessive accumulation of metabolites of the drug. When existing chronic liver disease (cirrhosis), a decrease in the total concentration of naproxen in plasma against a background of increasing its fractions, not related to serum albumin. In view of this patient with severe hepatic impairment is recommended to reduce by half the dose of the drug. In elderly patients the level of non-whites naproxen in plasma increased, although its overall concentration is not affected. In this regard, caution should be exercised in the appointment of high doses of the drug to these patients. Not recommended to prescribe a drug to children under 1 year. Pregnancy, breast-feeding 1 st and 2 nd trimesters of pregnancy. Despite the fact that in animal experiments Naprosyn had no teratogenic effects, assign it during pregnancy is recommended only if there is absolute evidence. The third trimester of pregnancy. Naprosyn should not be prescribed because of the possibility of oppression of labor in the mother and premature buried ductus arteriosus in the fetus. Naprosyn is not recommended for lactating mothers. Naproxen enters in small quantities in breast milk, where its concentration reaches about 1% of plasma concentrations.
Naprosyn Drug Interactions
Due to the high degree of binding Naprosyna serum proteins must be carefully observe patients while receiving hydantoin, since they may require a dosage adjustment. Despite the fact that in clinical trials of drug interactions with anticoagulants and sulfonylureas have been reported, it is still recommended to exercise some caution, since there are reports of interaction Naprosyna with other drugs belonging to this class of substances. Concomitant use of probenecid increases the level of naproxen in the blood and velichivaet during its half-life. In addition, it has been reported following drug interactions Naprosyna or other nonsteroidal anti-inflammatory drugs: the weakening of natriuretic effect of furosemide, inhibition of renal clearance of lithium decrease the hypotensive action of propranolol and other b-adrenoceptor blockers, slowing elimination of methotrexate in the urine. Since Naprosyn may cause artifacts when using certain methods of determining 17-ketosteroids, it is recommended to interrupt the treatment with 48 hours prior to study adrenal function. Naprosyn is also able to influence the outcome of determining the concentration of 5-oxyindoleacetic acid in urine. Naprosyn reversibly reduces platelet aggregation and prolong bleeding time. This effect must be considered when determining the bleeding time.
Naprosyn Overdose
Symptoms: dizziness, heartburn, indigestion, nausea, vomiting, seizures. Treatment: gastric lavage and / or the immediate introduction into aktivirovannoto coal, reduces the absorption of Naprosyna.
Terms and conditions of storage of Naprosyn
The drug should not be used after the expiry date (EXP) printed on the package.
Form release Naprosyn
Tablets 20, 100
Keep out of reach of children.
