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Pharmacological Effects Mexitil 

Antiarrhythmic, membrane stabilizing, местноанестезирующее.Всасывание from the gastrointestinal tract up to 90%, the maximum concentration is achieved in 2-4 hours. Therapeutic concentration of 0,75-2 mg / ml. After iv administration the plasma concentration decreases rapidly, the state of stable equilibrium occurs within 1 to 3 days. The half-life varies between 8-20 hours. Completely metabolized in the liver to form inactive metabolites. Excreted mainly by the liver, 10% - in the urine in unchanged vide.Effektiven in the treatment of ventricular arrhythmias in patients with acute myocardial infarction.  

Indications for use Mexitil 

Prevention and treatment of life-threatening ventricular arrhythmia (high grade - the frequent, paired), ventricular tachycardia. 

Contra Mexitil 

Hypersensitivity (including to other local anesthetics of the amide group), AV block II-III degree, cardiogenic shock, severe heart failure, bradycardia below 50 beats / min, hypotension, sick sinus syndrome, lesion of the conduction system of the heart , abnormal liver function and kidney disease, epilepsy, mental illness, pregnancy and lactation. 

Side effects of Mexitil  

Headaches, dizziness, nervousness, insomnia, paresthesia, muscle tremors, incoordination, seizures, visual disturbances, chest pain, peripheral edema, increased ventricular arrhythmias, nausea, vomiting, heartburn, liver damage, decreased blood pressure, bradycardia, leukopenia, thrombocytopenia, skin rash. 

Interaction Mexitil 

Increases the level of theophylline in the blood. Increase (each) of lidocaine toxicity. Antiarrhythmic effect of increases on the background of quinidine, beta-blockers and amiodarone. Rifampin and phenytoin accelerate the biotransformation and reduced the plasma concentration. Antacids, narcotic analgesics, sedatives, anticholinergics, including ganglioplegic, antihistamines, H2-blockers slow the absorption, metoclopramide - increases. Sodium bicarbonate and diuretics, alkalify urine, reduce excretion. 

Overdose Mexitil  

Symptoms: hypotension, bradycardia, conduction disturbances, nausea, paresthesia, epileptoid seizure, dysarthria, diplopia, nystagmus, disturbances soznaniya.Lechenie symptomatic. To speed up the elimination recommended the appointment of agents, acidifying the urine (ammonium chloride, ascorbic acid). Hemodynamic effects of adjusted intravenous 0,5-1 mg of atropine sulfate. Showed hemodialysis. 

Special instructions Mexitil  

You must be careful when assigning patients with severe heart failure. It is not recommended to quickly increase the dose. If abnormal liver function initial daily dose is decreased by half. Increase the level of aspartate transaminase is a prerequisite for the termination of treatment. In the transition from Class IA antiarrhythmic drugs on Valium necessary intervals: 6-12 hours after the last dose of quinidine and disopyramide, 3-6 hours - novokainamid; infusion of lidocaine terminated simultaneously with the first dose of Valium inside, but the system for infusion is not disconnected from the patient ( possible recurrence). In connection with the risk of life-threatening arrhythmias cancellation prior antiarrhythmic therapy is carried out in stationary conditions.