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Buy Imuran
This drug is in the category: "Pain medicine"
Imuran (AZATHIOPRINE) is an immunosuppressive agent used to prevent rejection after a kidney transplant. It may also be used to treat rheumatoid arthritis and other conditions as determined by your doctor.
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Before you buy, read the description of the drug.
Imuran
Structure and Composition Imuran
Coated tablets 1 tab.
azathioprine 50 mg
Excipients: lactose monohydrate, corn starch, pregelatinized starch; magnesium stearate, stearic acid. Coated tablet: gipermelloza, macrogol 400 (at pelletization, and applying the shell as a solvent used purified water, which removed during the manufacturing process and finished products is not present)
Pharmacodynamics Imuran
Inhibits the growth and development of immune cells (lymphocytes, plasma cells), affects on cooperative immune response (T lymphocytes, macrophages-B-lymphocytes), inhibits the migration of stem cells. In large doses (10 mg / kg) inhibits the function of bone marrow, inhibits proliferation granulocytes, causing leukopenia.
Prescribed drug Imuran ®
Organ transplants, severe rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, chronic active hepatitis, pemphigus vulgaris, periarteritis nodosa, hemolytic anemia, chronic idiopathic thrombocytopenic purpura.
Contra Imuran
Hypersensitivity (including a 6-mercaptopurine).
Application of pregnancy and breastfeeding
Contraindicated.
Side effects of the drug Imuran ®
Mielodepressiya (leukopenia, thrombocytopenia, anemia), megaloblastic erythropoiesis and macrocytosis, nausea, vomiting, anorexia, rash, arthralgia, myalgia, drug fever, cholestatic hepatitis, development of secondary infections in transplant recipients - erosive ulceration and bleeding from the gastrointestinal tract, pancreatitis, necrosis and perforation of the bowel, is rare - acute renal failure, hemolytic anemia, acute lung disease, meningeal reaction.
Interaction Imuran
Enhances the effect of depolarizing muscle relaxants and weakens - nondepolarizing. Immunosuppression potentiate allopurinol, oksipurinol, tiopurinol.
Administration and Dosage Imuran
Inside. Adults and children.
Application in organ transplantation: up to 5 mg / kg / day the first day of therapy, maintenance dose - 1-4 mg / kg / day depending on clinical indications and hematologic tolerance. Even in the case of low-dose maintenance therapy Imuranom should be carried out indefinitely long as there is a risk of graft rejection.
Application of recurrent form of multiple sclerosis: 2-3 mg / kg / day to achieve the effect may require treatment duration of 1 year. Monitor the progression disease is not always possible after 2 years of therapy.
Application for other conditions: an initial dose of 1-3 mg / kg / day and should be chosen in this range of doses depending on the clinical effect (which can not be obtained within weeks and months of starting treatment) and changes in blood counts. If the therapeutic effect obtained, it is necessary to reduce the maintenance dose to the minimum level at which saved to take effect. If within 3 months of clinical effect is not achieved, then Imuran should be abolished. However, in inflammatory bowel disease treatment should be carried out by at least for 12 months, and the therapeutic effect can be achieved in 3-4 months.
Maintenance dose can vary from less than 1 to 3 mg / kg / day, and is determined by disease as well as individual patient response.
Experience in applying Imurana in elderly patients is limited. Although the available data, the incidence of side effects in elderly do not exceed those of other patients taking Imuran, they should use the minimum dosage recommended dose range. Particular attention should be be paid to monitoring of haematological parameters, reduction of maintenance dose of up to minimum allowable to keep the therapeutic effect.
In patients with renal and / or hepatic insufficiency should apply the minimum dose therapeutic range.
Precautions Imuran
In the first 8 weeks of therapy requires weekly complete blood count. With careful use with
kidney and liver failure. When combined with the appointment of allo-, hydroxy-, tiopurinolom dose should be reduced by 4 times.
Storage conditions of the drug Imuran ®
In the dark place at a temperature not exceeding 25 ° C. List A.
Shelf life of the drug Imuran ®
5 years





