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Buy Danazol
This drug is in the category: "Women's health"
Danazol may be used for a number of different medical problems. These include treatment of:
Pain and/or infertility due to endometriosis;
A tendency for females to develop cysts in the breasts (fibrocystic breast disease); or
Hereditary angioedema, which causes swelling of the face, arms, legs, throat, windpipe, bowels, or sexual organs.
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Before you buy, read the description of the drug.
Danazol
Pharmacological action of Danazol
Inhibitor of gonadotropin-releasing hormone production. Causes a reversible suppression of the production of LH and FSH pituitary gland in both men and women. Does not have estrogenic activity and progestogens. Has a weak androgenic activity with concomitant anabolic effektom.Podavlyaet proliferation and causes atrophy of normal and ectopic tissue endometriya.Umenshaet loss of menstrual blood, the mechanism of action not fully installed. Inhibits ovulation and reduces the level of 17β-estradiol in the blood plasma. It remains unclear whether the inhibition of proliferation of the endometrium due to a decrease estradiol levels or a direct effect on estrogen receptor Danazola endometriya.Posle cancel Danazola ovulation usually resumes within 5 weeks, accompanied by a characteristic sharp increase in LH and a slight increase in FSH.
Pharmacokinetics Danazol
After oral Danazol absorbed from the gastrointestinal tract. Absorbance increases while eating. Metabolized in the liver, the main metabolite is 2-gidroksimetiltestosteron. T1 / 2 is about 4.5 hours
Indications Danazol
Endometriosis associated with infertility, benign tumors of the breast, primary menorrhagia, premenstrual syndrome, gynecomastia.
Dosage Danazol
Dose, the multiplicity of admission and duration of treatment are determined individually. The maximum dose for adults - 800 mg /
Side effects of Danazol
From the endocrine system: amenorrhea, flushing, increased sweating, reducing the size of the mammary glands, changes in libido, vaginitis, emotional lability, nervousness, acne, increased secretion of the sebaceous glands, a slight hirsutism, edema, weight gain, coarsening of the voice, androgenic alopecia, disturbances of spermatogenesis. From the digestive system: dysfunction of the gastrointestinal tract, increased liver enzymes, rarely - cholestatic jaundice. CNS: possible headache, dizziness, tremor, depression, fatigue, sleep disturbance, rarely - a small increase in intracranial pressure. From the hemopoietic system: an increase or decrease in the number of blood cells.
Dermatological reactions Danazol: skin rash.
From a metabolism: giperglyukagonemiya, violations of glucose tolerance, an increase in serum LDL cholesterol, decrease serum concentrations of HDL cholesterol. With the cardiovascular system: rarely - tachycardia, hypertension. Other: back pain, muscle spasms or convulsions, rarely - visual impairment.
Contra Danazol
Severe liver damage and / or kidneys, heart, porphyria, thromboembolic disorders (including history), androgenozavisimye tumors, vaginal bleeding of unknown origin, pregnancy, lactation. Application of pregnancy and breastfeeding Contraindicated in pregnancy and lactation. In women of childbearing age before starting the application Danazola to exclude pregnancy. Since Danazol is not a contraceptive, a treatment period should use nonhormonal methods of contraception.
Special instructions Danazol
With careful use in patients with liver disease, kidney disease, hypertension and other cardiovascular diseases, and conditions that may deteriorate due to fluid retention (including diabetes, epilepsy, polycythemia, lipid metabolism). Danazol is not recommended for use in the elderly and children.
Drug interactions Danazol
Danazol inhibits the metabolism in the liver carbamazepine, cyclosporin. Reported hypercalcemia caused Danazolom, against the background of alfacalcidol in a patient with gipoparatireoidizmom.
